Ontology highlight
ABSTRACT:
SUBMITTER: Molas S
PROVIDER: S-EPMC5752132 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Molas Susanna S Zhao-Shea Rubing R Liu Liwang L DeGroot Steven R SR Gardner Paul D PD Tapper Andrew R AR
Nature neuroscience 20170717 9
Novelty preference (NP) is an evolutionarily conserved, essential survival mechanism often dysregulated in neuropsychiatric disorders. NP is mediated by a motivational dopamine signal that increases in response to novel stimuli, thereby driving exploration. However, the mechanism by which once-novel stimuli transition to familiar stimuli is unknown. Here we describe a neuroanatomical substrate for familiarity signaling, the interpeduncular nucleus (IPN) of the midbrain, which is activated as nov ...[more]