Ontology highlight
ABSTRACT:
SUBMITTER: Edwards AK
PROVIDER: S-EPMC5752265 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
JCI insight 20171102 21
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood. We have found that NOTCH3, a critical regulator of mural cell differentiation and maturation, is expressed in hemangioma stem cells (HemSCs), suggesting that NOTCH3 may function in HemSC-to-mural cell differentiation and pathological vessel stabilization. Here, we demonstrate that NOTCH3 is expressed in NG2+PDGFRβ+ perivascular HemSC ...[more]