Ontology highlight
ABSTRACT:
SUBMITTER: Klebanoff CA
PROVIDER: S-EPMC5752304 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Klebanoff Christopher A CA Crompton Joseph G JG Leonardi Anthony J AJ Yamamoto Tori N TN Chandran Smita S SS Eil Robert L RL Sukumar Madhusudhanan M Vodnala Suman K SK Hu Jinhui J Ji Yun Y Clever David D Black Mary A MA Gurusamy Devikala D Kruhlak Michael J MJ Jin Ping P Stroncek David F DF Gattinoni Luca L Feldman Steven A SA Restifo Nicholas P NP
JCI insight 20171207 23
Adoptive immunotherapies using T cells genetically redirected with a chimeric antigen receptor (CAR) or T cell receptor (TCR) are entering mainstream clinical practice. Despite encouraging results, some patients do not respond to current therapies. In part, this phenomenon has been associated with infusion of reduced numbers of early memory T cells. Herein, we report that AKT signaling inhibition is compatible with CAR and TCR retroviral transduction of human T cells while promoting a CD62L-expr ...[more]