Ontology highlight
ABSTRACT:
SUBMITTER: Onyema OO
PROVIDER: S-EPMC5752306 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Onyema Oscar Okwudiri OO Guo Yizhan Y Wang Qing Q Stoler Mark H MH Lau Christine C Li Kang K Nazaroff Christopher Daniel CD Wang Xingan X Li Wenjun W Kreisel Daniel D Gelman Andrew E AE Lee James J JJ Jacobsen Elizabeth A EA Krupnick Alexander Sasha AS
JCI insight 20171221 24
Lungs allografts have worse long-term survival compared with other organ transplants. This is most likely due to their unique immunoregulation that may not respond to traditional immunosuppression. For example, local NO generation by inducible NOS (iNOS) is critical for lung allograft acceptance but associates with rejection of other solid organs. The source of NO in accepting lung allografts remains unknown. Here, we report that, unlike the case for other pulmonary processes in which myeloid ce ...[more]