Dataset Information

Hyperglycemia combined Helicobacter pylori infection increases risk of synchronous colorectal adenoma and carotid artery plaque.

ABSTRACT:

Background

Cardiovascular disease and colorectal cancer have severe consequences to human health and may occur simultaneously or sequentially. Carotid artery plaque is a predictor of cardiovascular disease, and colorectal adenoma is a premalignant lesion of colorectal cancer. We investigated the core risk factors of carotid artery plaque and colorectal adenoma.

Results

In total, 2361 subjects were enrolled. In multivariate analysis, age ? 60 years, male sex, BMI > 27, LDL > 130 mg/dL, HbA_1c ? 6.5%, hs-CRP > 0.3 mg/L and H. pylori infection were independent risk factors for synchronous colorectal adenoma and carotid artery plaque formation. In the H. pylori-positive and -negative groups, the proportions and odds ratio (OR) for synchronous colon adenoma and carotid artery plaque increased with increasing HbA1c. OR for synchronous colon adenoma and carotid artery plaque was significantly higher in the participants with HbA_1c levels of 5.7%-6.4% and HbA1c ? 6.5% than in those with normal HbA_1c in the H. pylori-negative group. The OR was more significant increased for H. pylori-positive patients when HbA_1c level ? 6.5% was 15.87 (95% CI 8.661-29.082, p < 0.0001).

Materials and methods

The records of 4669 subjects aged > 40 years who underwent bidirectional gastrointestinal endoscopy and carotid artery ultrasound examination on the same day or within 12 months of endoscopy examination from January 2006 to December 2015 were reviewed. All subjects had a gastric biopsy specimen tested for Helicobacter pylori.

Conclusions

Hyperglycemia combined with H. pylori infection was an increased risk factor for synchronous colorectal adenoma and carotid artery plaque formation. Diabetes control and H. pylori eradication may be warranted in higher prevalence areas.

SUBMITTER: Hu KC

PROVIDER: S-EPMC5752471 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Hyperglycemia combined <i>Helicobacter pylori</i> infection increases risk of synchronous colorectal adenoma and carotid artery plaque.

Hu Kuang-Chun KC Wu Ming-Shiang MS Chu Cheng-Hsin CH Wang Horng-Yuan HY Lin Shee-Chan SC Po Helen L HL Bair Ming-Jong MJ Liu Chuan-Chuan CC Su Tung-Hung TH Chen Chi-Ling CL Liu Chun-Jen CJ Shih Shou-Chuan SC

Oncotarget 20171026 65

<h4>Background</h4>Cardiovascular disease and colorectal cancer have severe consequences to human health and may occur simultaneously or sequentially. Carotid artery plaque is a predictor of cardiovascular disease, and colorectal adenoma is a premalignant lesion of colorectal cancer. We investigated the core risk factors of carotid artery plaque and colorectal adenoma.<h4>Results</h4>In total, 2361 subjects were enrolled. In multivariate analysis, age ≥ 60 years, male sex, BMI > 27, LDL > 130 mg ...[more]

PMID: 29312558

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