Ontology highlight
ABSTRACT:
SUBMITTER: Gudernova I
PROVIDER: S-EPMC5752523 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Gudernova Iva I Balek Lukas L Varecha Miroslav M Kucerova Jana Fialova JF Kunova Bosakova Michaela M Fafilek Bohumil B Palusova Veronika V Uldrijan Stjepan S Trantirek Lukas L Krejci Pavel P
Oncotarget 20171127 65
Many tyrosine kinase inhibitors (TKIs) have failed to reach human use due to insufficient activity in clinical trials. However, the failed TKIs may still benefit patients if their other kinase targets are identified by providing treatment focused on syndromes driven by these kinases. Here, we searched for novel targets of AZD1480, an inhibitor of JAK2 kinase that recently failed phase two cancer clinical trials due to a lack of activity. Twenty seven human receptor tyrosine kinases (RTKs) and 15 ...[more]