Ontology highlight
ABSTRACT:
SUBMITTER: Garcia PL
PROVIDER: S-EPMC5752593 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Garcia Patrick L PL Miller Aubrey L AL Gamblin Tracy L TL Council Leona N LN Christein John D JD Arnoletti J Pablo JP Heslin Marty J MJ Reddy Sushanth S Richardson Joseph H JH Cui Xiangqin X van Waardenburg Robert C A M RCAM Bradner James E JE Yang Eddy S ES Yoon Karina J KJ
Molecular cancer therapeutics 20171115 1
Cholangiocarcinoma (CCA) is a fatal disease with a 5-year survival of <30%. For a majority of patients, chemotherapy is the only therapeutic option, and virtually all patients relapse. Gemcitabine is the first-line agent for treatment of CCA. Patients treated with gemcitabine monotherapy survive ∼8 months. Combining this agent with cisplatin increases survival by ∼3 months, but neither regimen produces durable remissions. The molecular etiology of this disease is poorly understood. To facilitate ...[more]