Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee S
PROVIDER: S-EPMC5752618 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Banerjee Siddhartha S Sun Zhiqiang Z Hayden Eric Y EY Teplow David B DB Lyubchenko Yuri L YL
ACS nano 20171129 12
Amyloid β-protein (Aβ) oligomers are emerging as potent neurotoxic species in Alzheimer's disease pathogenesis. Detailed characterization of oligomer structure and dynamics is necessary to develop oligomer-specific therapeutic agents. However, oligomers exist transiently, which complicates their structural analysis. One approach to mitigate these problems has been photochemical cross-linking of native oligomers. In these states, the oligomers can be isolated and purified for physical and chemica ...[more]