Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies.

ABSTRACT:

Background

Avenanthramides (AVA) are a group of diphenolic acids found only in oats that have anti-inflammatory and antioxidant effects. Absorption of AVAs in humans after oral consumption of natural oat flour is unknown.

Objective

To examine the appearance of AVAs in plasma after oral ingestion of oat cookies and estimate key pharmacokinetic parameters.

Methods

Male and female nonobese participants (n = 16) consumed three cookies made with oat flour containing high (229.6 mg/kg, H-AVA) or low (32.7 mg/kg, L-AVA) amounts of AVAs, including AVA-A, AVA-B, and AVA-C. Blood samples were collected at 0, 0.5, 1, 2, 3, 5, and 10 h after ingestion. Plasma total (conjugated and free) AVA concentrations were quantified using UPLC-MS, and pharmacokinetic parameters for ea

SUBMITTER: Zhang T 

PROVIDER: S-EPMC5752969 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature