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The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers.

ABSTRACT: The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding syn-diastereomer. Both targets were synthesised using an epoxide opening strategy.

SUBMITTER: Szpera R

PROVIDER: S-EPMC5753060 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers.

Szpera Robert R Kovalenko Nadia N Natarajan Kalaiselvi K Paillard Nina N Linclau Bruno B

Beilstein journal of organic chemistry 20171227

The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of <i>anti</i>-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corresponding <i>syn</i>-diastereomer. Both targets were synthesised using an epoxide opening strategy. ...[more]

PMID: 30018668

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