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MiRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.


ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs of ? 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ?1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.

SUBMITTER: Chou CH 

PROVIDER: S-EPMC5753222 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.

Chou Chih-Hung CH   Shrestha Sirjana S   Yang Chi-Dung CD   Chang Nai-Wen NW   Lin Yu-Ling YL   Liao Kuang-Wen KW   Huang Wei-Chi WC   Sun Ting-Hsuan TH   Tu Siang-Jyun SJ   Lee Wei-Hsiang WH   Chiew Men-Yee MY   Tai Chun-San CS   Wei Ting-Yen TY   Tsai Tzi-Ren TR   Huang Hsin-Tzu HT   Wang Chung-Yu CY   Wu Hsin-Yi HY   Ho Shu-Yi SY   Chen Pin-Rong PR   Chuang Cheng-Hsun CH   Hsieh Pei-Jung PJ   Wu Yi-Shin YS   Chen Wen-Liang WL   Li Meng-Ju MJ   Wu Yu-Chun YC   Huang Xin-Yi XY   Ng Fung Ling FL   Buddhakosai Waradee W   Huang Pei-Chun PC   Lan Kuan-Chun KC   Huang Chia-Yen CY   Weng Shun-Long SL   Cheng Yeong-Nan YN   Liang Chao C   Hsu Wen-Lian WL   Huang Hsien-Da HD  

Nucleic acids research 20180101 D1


MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ∼1.4-fold since t  ...[more]

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