Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid ?.
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ABSTRACT:
SUBMITTER: Uematsu M
PROVIDER: S-EPMC5753447 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β.
Uematsu Miho M Nakamura Ayako A Ebashi Momoko M Hirokawa Katsuiku K Takahashi Ryosuke R Uchihara Toshiki T
Acta neuropathologica communications 20180103 1
<h4>Introduction</h4>Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau progressively increases. If this preferential accumulation of 3R tau also occurs in the brainstem, it may be fundamentally related to progression of Alzheimer pathology.<h4>Methods</h4>Midbrain and pontine sections of brainstems from 23 cases (Braak-NFT ...[more]
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