Ontology highlight
ABSTRACT:
SUBMITTER: Moffett HF
PROVIDER: S-EPMC5753758 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature immunology 20170522 7
During infection, antigen-specific T cells undergo tightly regulated developmental transitions controlled by transcriptional and post-transcriptional regulation of gene expression. We found that the microRNA miR-31 was strongly induced by activation of the T cell antigen receptor (TCR) in a pathway involving calcium and activation of the transcription factor NFAT. During chronic infection with lymphocytic choriomeningitis virus (LCMV) clone 13, miR-31-deficent mice recovered from clinical diseas ...[more]