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Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.

ABSTRACT: A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2-4 and the two lycorane alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodial activity, while compounds 3 and 4 were moderately active, and compounds 1 and 6 were inactive.

SUBMITTER: Cho N

PROVIDER: S-EPMC5753767 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.

Cho Namki N Du Yongle Y Valenciano Ana Lisa AL Fernández-Murga Maria L ML Goetz Michael M Clement Jason J Cassera Maria B MB Kingston David G I DGI

Bioorganic & medicinal chemistry letters 20171111 1

A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2-4 and the two lycorane alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodia ...[more]

PMID: 29162457

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