Ontology highlight
ABSTRACT:
SUBMITTER: Cho N
PROVIDER: S-EPMC5753767 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cho Namki N Du Yongle Y Valenciano Ana Lisa AL Fernández-Murga Maria L ML Goetz Michael M Clement Jason J Cassera Maria B MB Kingston David G I DGI
Bioorganic & medicinal chemistry letters 20171111 1
A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2-4 and the two lycorane alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodia ...[more]