Ontology highlight
ABSTRACT:
SUBMITTER: Xue C
PROVIDER: S-EPMC5753800 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Cell reports 20171201 13
CRISPR-Cas systems defend bacteria and archaea against infection by bacteriophage and other threats. The central component of these systems are surveillance complexes that use guide RNAs to bind specific regions of foreign nucleic acids, marking them for destruction. Surveillance complexes must locate targets rapidly to ensure timely immune response, but the mechanism of this search process remains unclear. Here, we used single-molecule FRET to visualize how the type I-E surveillance complex Cas ...[more]