Isolation of Aggressive Behavior Mutants in Drosophila Using a Screen for Wing Damage.

ABSTRACT: Aggression is a complex social behavior that is widespread in nature. To date, only a limited number of genes that affect aggression have been identified, in large part because the complexity of the phenotype makes screening difficult and time-consuming regardless of the species that is studied. We discovered that aggressive group-housed Drosophila melanogaster males inflict damage on each other's wings, and show that wing damage negatively affects their ability to fly and mate. Using this wing-damage phenotype, we screened males from ∼1400 chemically mutagenized strains and found ∼40 mutant strains with substantial wing damage. Five of these mutants also had increased aggressive behavior. To identify the causal mutation in one of our top aggressive strains, we used whole-genome seq

SUBMITTER: Davis SM 

PROVIDER: S-EPMC5753862 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature