Ontology highlight
ABSTRACT:
SUBMITTER: Gerlits OO
PROVIDER: S-EPMC5754002 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Biochemistry 20170830 36
Plant lectins are carbohydrate-binding proteins with various biomedical applications. Concanavalin A (Con A) holds promise in treating cancerous tumors. To better understand the Con A carbohydrate binding specificity, we obtained a room-temperature neutron structure of this legume lectin in complex with a disaccharide Manα1-2Man, mannobiose. The neutron structure afforded direct visualization of the hydrogen bonding between the protein and ligand, showing that the ligand is able to alter both pr ...[more]