Ontology highlight
ABSTRACT:
SUBMITTER: Nakashige TG
PROVIDER: S-EPMC5754018 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nakashige Toshiki G TG Zygiel Emily M EM Drennan Catherine L CL Nolan Elizabeth M EM
Journal of the American Chemical Society 20170622 26
The human innate immune protein calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/calgranulin B oligomer, MRP-8/MRP-14 oligomer) chelates a number of first-row transition metals, including Mn(II), Fe(II), and Zn(II), and can withhold these essential nutrients from microbes. Here we elucidate the Ni(II) coordination chemistry of human CP. We present a 2.6-Å crystal structure of Ni(II)- and Ca(II)-bound CP, which reveals that CP binds Ni(II) ions at both its transition-metal-binding sites: t ...[more]