Dataset Information

Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.

ABSTRACT:

Objective

Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors.

Design and methods

A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected including oral glucose tolerance testing and urinary OT (measured by ELISA). Subjects also completed questionnaires on social and lifestyle factors.

Results

OT levels were found to be significantly lower in subjects with type 2 diabetes mellitus (T2DM) compared to normal glucose tolerance (p<0.05). When stratified by OT tertiles, subjects with higher OT had lower weight, body mass index (BMI) and hemoglobin A1c, but higher eGFR which remained significant after BMI adjustment. The highest OT tertile also had more smokers and more users of psychiatric medications. A stepwise ordered logistic regression supported these findings and could account for 21% of the variation in OT categories (pseudoR2 = 0.21).

Conclusions

In this unique population, OT was found lower in subjects with diabetes but higher with better renal function, cigarette smoking and use of psychiatric medications. Future studies are needed to confirm these findings and examine the potential therapeutic role of OT.

SUBMITTER: Eisenberg Y

PROVIDER: S-EPMC5754076 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.

Eisenberg Yuval Y Dugas Lara R LR Akbar Arfana A Reddivari Bharathi B Layden Brian T BT Barengolts Elena E

PloS one 20180104 1

<h4>Objective</h4>Recently, it has been suggested that oxytocin (OT) has a role in metabolism and neuropsychiatry health and disease, and therefore, it may represent a potential therapeutic target. The current study aimed to investigate relationships between OT and glycemic status along with psycho-social and behavioral factors.<h4>Design and methods</h4>A total of 92 obese or overweight, African American, male subjects were enrolled in the study. Biometric and biochemical data were collected in ...[more]

PMID: 29300770

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Dataset Information

Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.

Objective

Design and methods

Results

Conclusions

Publications

Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.

Similar Datasets

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