Ontology highlight
ABSTRACT:
SUBMITTER: Man J
PROVIDER: S-EPMC5756127 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell stem cell 20171130 1
Tumor hypoxia is associated with poor patient survival and is a characteristic of glioblastoma. Notch signaling is implicated in maintaining glioma stem-like cells (GSCs) within the hypoxic niche, although the molecular mechanisms linking hypoxia to Notch activation have not been clearly delineated. Here we show that Vasorin is a critical link between hypoxia and Notch signaling in GSCs. Vasorin is preferentially induced in GSCs by a HIF1α/STAT3 co-activator complex and stabilizes Notch1 protein ...[more]