Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
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ABSTRACT:
SUBMITTER: Xue WH
PROVIDER: S-EPMC5757122 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
Xue Wen-Hua WH Fan Zhi-Rui ZR Li Li-Feng LF Lu Jing-Li JL Ma Bing-Jun BJ Kan Quan-Cheng QC Zhao Jie J
World journal of gastroenterology 20180101 1
<h4>Aim</h4>To explore the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and mRNAs in oesophageal squamous cell carcinoma (ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA (ceRNA) network.<h4>Methods</h4>In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.<h4>Results</h4>CeRNAs have the ability to reduce the targetin ...[more]
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