Ontology highlight
ABSTRACT:
SUBMITTER: Beisaw A
PROVIDER: S-EPMC5757217 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Beisaw Arica A Tsaytler Pavel P Koch Frederic F Schmitz Sandra U SU Melissari Maria-Theodora MT Senft Anna D AD Wittler Lars L Pennimpede Tracie T Macura Karol K Herrmann Bernhard G BG Grote Phillip P
EMBO reports 20171115 1
T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (T<sup>Y88A</sup>) results in decreased histone 3 lysine 27 acetylation (H3K27ac) at T target sites, including the <i>T</i> locus, suggesting that T autoregulates the maintenance of its expression and functions by recruiting permissive chromatin modifica ...[more]