Ontology highlight
ABSTRACT:
SUBMITTER: Mullins C
PROVIDER: S-EPMC5757244 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Neuron 20160301 6
Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a challenging goal. Here we review recent progress on several fronts, including genetics, proteomics, biochemistry, and electrophysiology, that raise motivation for forming a viable pathophysiological hypothesis. In place of a traditionally unidirectional progression, we put forward a framework that extends homeostatic hypotheses by explicitly emphasizing autoregulatory feedback loops and known synaptic biology. The regu ...[more]