Ontology highlight
ABSTRACT:
SUBMITTER: Tan CH
PROVIDER: S-EPMC5758043 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Annals of neurology 20170901 3
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older ind ...[more]