Ontology highlight
ABSTRACT:
SUBMITTER: Lamm KYB
PROVIDER: S-EPMC5758111 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Lamm Katherine Young Bezold KYB Johnson Maddison L ML Baker Phillips Julie J Muntifering Michael B MB James Jeanne M JM Jones Helen N HN Redline Raymond W RW Rokas Antonis A Muglia Louis J LJ
eLife 20180108
Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of <i>Inverted formin 2</i> (<i>INF2)</i> alters intracellular trafficking and significantly impairs invasion in a model of human extravillous trophoblasts. Furthermore, globa ...[more]