Ontology highlight
ABSTRACT:
SUBMITTER: Yan T
PROVIDER: S-EPMC5758779 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180108 1
The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hTERT expression. mir-615-3p is located in an intron of the HOXC5 gene, a member of the highly conserved homeobox family of transcription factors controlling embryogenesis and development. Unexpectedly, ...[more]