Unknown

Dataset Information

0

Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial.


ABSTRACT: Background:Anorexia occurs in about half of cancer patients and is associated with high mortality rate. However, safe and long-term use of anorexia treatment is still an unmet need. Objective:The purpose of the present study was to examine the feasibility of Sipjeondaebo-tang (Juzen-taiho-to, Shi-Quan-Da-Bu-Tang) for cancer-related anorexia. Methods:A total of 32 participants with cancer anorexia were randomized to either Sipjeondaebo-tang group or placebo group. Participants were given 3?g of Sipjeondaebo-tang or placebo 3 times a day for 4 weeks. The primary outcome was a change in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT). The secondary outcomes included Visual Analogue Scale (VAS) of anorexia, FAACT scale, and laboratory tests. Results:Anorexia and quality of life measured by FAACT and VAS were improved after 4 weeks of Sipjeondaebo-tang treatment. However, there was no significant difference between changes of Sipjeondaebo-tang group and placebo group. Conclusions:In the present study, [corrected] Sipjeondaebo-tang did not show a significant effect on anorexia [corrected]in patients with cancer. Further large-scale studies which compensate for the limitations of this study are needed to assess [corrected] the efficacy. Trial Registration:This trial is registered with ClinicalTrials.gov NCT02468141.

SUBMITTER: Cheon C 

PROVIDER: S-EPMC5758845 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial.

Cheon Chunhoo C   Yoo Jeong-Eun JE   Yoo Hwa-Seung HS   Cho Chong-Kwan CK   Kang Sohyeon S   Kim Mia M   Jang Bo-Hyoung BH   Shin Yong-Cheol YC   Ko Seong-Gyu SG  

Evidence-based complementary and alternative medicine : eCAM 20171226


<h4>Background</h4>Anorexia occurs in about half of cancer patients and is associated with high mortality rate. However, safe and long-term use of anorexia treatment is still an unmet need.<h4>Objective</h4>The purpose of the present study was to examine the feasibility of Sipjeondaebo-tang (Juzen-taiho-to, Shi-Quan-Da-Bu-Tang) for cancer-related anorexia.<h4>Methods</h4>A total of 32 participants with cancer anorexia were randomized to either Sipjeondaebo-tang group or placebo group. Participan  ...[more]

Similar Datasets

| S-EPMC8495912 | biostudies-literature
| S-EPMC6042596 | biostudies-literature
| S-EPMC6466777 | biostudies-literature
| S-EPMC4874172 | biostudies-other
| S-EPMC7578262 | biostudies-literature
| S-EPMC10213234 | biostudies-literature
| S-EPMC6647292 | biostudies-literature
| S-EPMC8063544 | biostudies-literature
| S-EPMC7607674 | biostudies-literature
| S-EPMC8779026 | biostudies-literature