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Blood phenylalanine instability strongly correlates with anxiety in phenylketonuria.

ABSTRACT: We assessed the relationship between anxiety and long-term metabolic control in adolescents with phenylketonuria (PKU). We used a standardized psychological test to measure anxiety level and analyzed lifelong blood phenylalanine stability in a selected group of 25 PKU teenagers with treatment adherence problems. We demonstrated significant correlations of anxiety with variability of blood phenylalanine concentrations and with severity of hyperphenylalaninemia. Avoiding blood phenylalanine fluctuations in childhood can probably reduce anxiety in PKU adolescents.

SUBMITTER: Didycz B

PROVIDER: S-EPMC5758931 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Blood phenylalanine instability strongly correlates with anxiety in phenylketonuria.

Didycz Bozena B Bik-Multanowski Miroslaw M

Molecular genetics and metabolism reports 20171227

We assessed the relationship between anxiety and long-term metabolic control in adolescents with phenylketonuria (PKU). We used a standardized psychological test to measure anxiety level and analyzed lifelong blood phenylalanine stability in a selected group of 25 PKU teenagers with treatment adherence problems. We demonstrated significant correlations of anxiety with variability of blood phenylalanine concentrations and with severity of hyperphenylalaninemia. Avoiding blood phenylalanine fluctu ...[more]

PMID: 29326880

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