Ontology highlight
ABSTRACT:
SUBMITTER: Shan J
PROVIDER: S-EPMC5760097 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Shan Jiaoyu J Zhao Binbin B Shan Zhao Z Nie Jia J Deng Rong R Xiong Rui R Tsun Andy A Pan Weiqi W Zhao Hanzhi H Chen Ling L Jin Ying Y Qian Zhikang Z Lui Kawing K Liang Rui R Li Dan D Sun Bing B Lavillette Dimitri D Xu Ke K Li Bin B
PLoS pathogens 20171227 12
The histone demethylase LSD1 has been known as a key transcriptional coactivator for DNA viruses such as herpes virus. Inhibition of LSD1 was found to block viral genome transcription and lytic replication of DNA viruses. However, RNA virus genomes do not rely on chromatin structure and histone association, and the role of demethylase activity of LSD1 in RNA virus infections is not anticipated. Here, we identify that, contrary to its role in enhancing DNA virus replication, LSD1 limits RNA virus ...[more]