Ontology highlight
ABSTRACT:
SUBMITTER: Mari A
PROVIDER: S-EPMC5760393 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Mari Andrea A D'Andrea David D Abufaraj Mohammad M Foerster Beat B Kimura Shoji S Shariat Shahrokh F SF
Translational andrology and urology 20171201 6
Bladder cancer (BCa) is burdened by high rates of chemo- and radio-resistance. We reviewed and summarized the current evidence regarding the genetic determinants of resistance in patients treated with chemotherapy and/or radiotherapy (RT) for BCa. Genetic heterogeneity may preexist to treatment arising with tumorigenesis or increasing progressively during the treatment. Several biological pathways seem to be involved in the cellular response to treatment. These pathways comprehend mechanisms lea ...[more]