Ontology highlight
ABSTRACT:
SUBMITTER: Choi HJ
PROVIDER: S-EPMC5760629 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Choi Hyun Jin HJ Park Areum A Kang Sujin S Lee Eunhye E Lee Taeyun A TA Ra Eun A EA Lee Jiseon J Lee Sungwook S Park Boyoun B
Nature communications 20180109 1
Human cytomegalovirus (HCMV) has evolved sophisticated immune evasion mechanisms that target both the innate and adaptive immune responses. However, how HCMV encoded proteins are involved in this immune escape is not clear. Here, we show that HCMV glycoprotein US9 inhibits the IFN-β response by targeting the mitochondrial antiviral-signaling protein (MAVS) and stimulator of interferon genes (STING)-mediated signaling pathways. US9 accumulation in mitochondria attenuates the mitochondrial membran ...[more]