Ontology highlight
ABSTRACT:
SUBMITTER: Blum CF
PROVIDER: S-EPMC5760630 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Blum C F CF Heramvand N N Khonsari A S AS Kollmann M M
Nature communications 20180109 1
Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks from gene knockout screens and introduce a network inference method that is unbiased with respect to measurement noise and scalable to large network sizes. We show that network asy ...[more]