Ontology highlight
ABSTRACT:
SUBMITTER: Shaw J
PROVIDER: S-EPMC5760633 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Shaw Joseph J Leveridge Mathew M Norling Charlotta C Karén Jakob J Molina Daniel Martinez DM O'Neill Daniel D Dowling James E JE Davey Paul P Cowan Suzanna S Dabrowski Michael M Main Martin M Gianni Davide D
Scientific reports 20180109 1
Androgen Receptor (AR) is a key driver in prostate cancer. Direct targeting of AR has valuable therapeutic potential. However, the lack of disease relevant cellular methodologies capable of discriminating between inhibitors that directly bind AR and those that instead act on AR co-regulators has made identification of novel antagonists challenging. The Cellular Thermal Shift Assay (CETSA) is a technology enabling confirmation of direct target engagement with label-free, endogenous protein in liv ...[more]