Ontology highlight
ABSTRACT:
SUBMITTER: Kirtane AR
PROVIDER: S-EPMC5760734 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180109 1
The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug-polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would signif ...[more]