Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans.

ABSTRACT:

Context

Abnormal glucagon concentrations contribute to hyperglycemia, but the mechanisms of α-cell dysfunction in prediabetes are unclear.

Objective

We sought to determine the relative contributions of insulin secretion and action to α-cell dysfunction in nondiabetic participants across the spectrum of glucose tolerance.

Design

This was a cross-sectional study. A subset of participants (n = 120) was studied in the presence and absence of free fatty acid (FFA) elevation, achieved by infusion of Intralipid (Baxter Healthcare, Deerfield, IL) plus heparin, to cause insulin resistance.

Setting

An inpatient clinical research unit at an academic medical center.

Participants

A total of 310 nondiabetic persons participated in this study.

Interventions

Part

SUBMITTER: Sharma A 

PROVIDER: S-EPMC5761487 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature