Ontology highlight
ABSTRACT:
SUBMITTER: Karremann M
PROVIDER: S-EPMC5761525 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Karremann Michael M Gielen Gerrit H GH Hoffmann Marion M Wiese Maria M Colditz Niclas N Warmuth-Metz Monika M Bison Brigitte B Claviez Alexander A van Vuurden Dannis G DG von Bueren André O AO Gessi Marco M Kühnle Ingrid I Hans Volkmar H VH Benesch Martin M Sturm Dominik D Kortmann Rolf-Dieter RD Waha Andreas A Pietsch Torsten T Kramm Christof M CM
Neuro-oncology 20180101 1
<h4>Background</h4>The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). Tumors of this entity arise in CNS midline structures of predominantly pediatric patients and are associated with an overall dismal prognosis. They are defined by K27M mutations in H3F3A or HIST1H3B/C, encoding for histone 3 variants H3.3 and H3.1, respectively, which are consider ...[more]