Ontology highlight
ABSTRACT:
SUBMITTER: Mata E
PROVIDER: S-EPMC5762329 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Mata Elena E Díaz-López Antonio A Martín-Moreno Ana M AM Sánchez-Beato Margarita M Varela Ignacio I Mestre María J MJ Santonja Carlos C Burgos Fernando F Menárguez Javier J Estévez Mónica M Provencio Mariano M Sánchez-Espiridión Beatriz B Díaz Eva E Montalbán Carlos C Piris Miguel A MA García Juan F JF
Oncotarget 20171130 67
Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe the mutational profile of a series of 57 cHL cases, enriched in Hodgkin and Reed-Sternberg (HRS) cells. Overall, the results confirm the presence of strong genomic heterogeneity. However, several variants were consistently detected in genes re ...[more]