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Pancreatic ? Cell Regeneration as a Possible Therapy for Diabetes.

ABSTRACT: Diabetes is the result of having inadequate supply of functional insulin-producing ? cells. Two possible approaches for replenishing the ? cells are: (1) replacement by transplanting cadaveric islets or ? cells derived from human embryonic stem cells/induced pluripotent stem cells and (2) induction of endogenous regeneration. This review focuses on endogenous regeneration, which can follow two pathways: enhanced replication of existing ? cells and formation of new ? cells from cells not expressing insulin, either by conversion from a differentiated cell type (transdifferentiation) or differentiation from progenitors (neogenesis). Exciting progress on both pathways suggest that regeneration may have therapeutic promise.

SUBMITTER: Aguayo-Mazzucato C

PROVIDER: S-EPMC5762410 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.

Aguayo-Mazzucato Cristina C Bonner-Weir Susan S

Cell metabolism 20170907 1

Diabetes is the result of having inadequate supply of functional insulin-producing β cells. Two possible approaches for replenishing the β cells are: (1) replacement by transplanting cadaveric islets or β cells derived from human embryonic stem cells/induced pluripotent stem cells and (2) induction of endogenous regeneration. This review focuses on endogenous regeneration, which can follow two pathways: enhanced replication of existing β cells and formation of new β cells from cells not expressi ...[more]

PMID: 28889951

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