Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Gurmaches J
PROVIDER: S-EPMC5762420 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Sanchez-Gurmaches Joan J Tang Yuefeng Y Jespersen Naja Zenius NZ Wallace Martina M Martinez Calejman Camila C Gujja Sharvari S Li Huawei H Edwards Yvonne J K YJK Wolfrum Christian C Metallo Christian M CM Nielsen Søren S Scheele Camilla C Guertin David A DA
Cell metabolism 20171116 1
Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus, understanding its metabolic circuitry is clinically important. Many studies of BAT compare rodents mildly cold to those severely cold. Here, we compared BAT remodeling between thermoneutral and mild-cold-adapted mice, conditions more relevant to humans. Although BAT is renowned for catabolic β-oxidative capacity, we find paradoxically that the anabolic de novo lipogenesis (DNL) genes encoding ACLY, ACSS2, ACC, and F ...[more]