Dataset Information

Development of cell metabolite analysis on microfluidic platform.

ABSTRACT: Cell metabolite analysis is of great interest to analytical chemists and physiologists, with some metabolites having been identified as important indicators of major diseases such as cancer. A high-throughput and sensitive method for drug metabolite analysis will largely promote the drug discovery industry. The basic barrier of metabolite analysis comes from the interference of complex components in cell biological system and low abundance of target substances. As a powerful tool in biosample analysis, microfluidic chip enhances the sensitivity and throughput by integrating multiple functional units into one chip. In this review, we discussed three critical steps of establishing functional microfluidic platform for cellular metabolism study. Cell in vitro culture model, on chip sample pretreatment, and microchip combined detectors were described in details and demonstrated by works in five years. And a brief summary was given to discuss the advantages as well as challenges of applying microchip method in cell metabolite and biosample analysis.

SUBMITTER: Lin L

PROVIDER: S-EPMC5762437 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Development of cell metabolite analysis on microfluidic platform.

Lin Luyao L Lin Jin-Ming JM

Journal of pharmaceutical analysis 20150930 6

Cell metabolite analysis is of great interest to analytical chemists and physiologists, with some metabolites having been identified as important indicators of major diseases such as cancer. A high-throughput and sensitive method for drug metabolite analysis will largely promote the drug discovery industry. The basic barrier of metabolite analysis comes from the interference of complex components in cell biological system and low abundance of target substances. As a powerful tool in biosample an ...[more]

PMID: 29403948

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Dataset Information

Development of cell metabolite analysis on microfluidic platform.

Publications

Development of cell metabolite analysis on microfluidic platform.

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