Ontology highlight
ABSTRACT:
SUBMITTER: Hirasawa A
PROVIDER: S-EPMC5762508 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hirasawa Akira A Imoto Issei I Naruto Takuya T Akahane Tomoko T Yamagami Wataru W Nomura Hiroyuki H Masuda Kiyoshi K Susumu Nobuyuki N Tsuda Hitoshi H Aoki Daisuke D
Oncotarget 20171128 68
Pathogenic germline <i>BRCA1</i>, <i>BRCA2</i> (<i>BRCA1/2</i>), and several other gene variants predispose women to primary ovarian, fallopian tube, and peritoneal carcinoma (OC), although variant frequency and relevance information is scarce in Japanese women with OC. Using targeted panel sequencing, we screened 230 unselected Japanese women with OC from our hospital-based cohort for pathogenic germline variants in 75 or 79 OC-associated genes. Pathogenic variants of 11 genes were identified i ...[more]