Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer.
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ABSTRACT:
SUBMITTER: Luo Y
PROVIDER: S-EPMC5762530 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer.
Luo Yajun Y Wang Cheng C Yong Peng P Ye Pengcheng P Liu Zilin Z Fu Zhiming Z Lu Fei F Xiang Wanping W Tan Wang W Xiao Jiangwei J
Oncotarget 20171107 68
Many lncRNA and mRNA sense-antisense transcripts have been systematically identified in malignant cells. However, the molecular mechanisms of most lncRNA-mRNA pairs in gastric cancer remain largely unknown. We found the gastric cancer-associated lncRNA SLC7A11-AS1 and coding transcript mRNA SLC7A11 in human gastric cancer specimens by microarray. SLC7A11-AS1, antisense to SLC7A11, is significantly down-regulated in gastric cancer and could promote tumor growth <i>in vitro</i> and <i>in vivo</i>. ...[more]
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