Ontology highlight
ABSTRACT:
SUBMITTER: Ogunbolude Y
PROVIDER: S-EPMC5762571 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ogunbolude Yetunde Y Dai Chenlu C Bagu Edward T ET Goel Raghuveera Kumar RK Miah Sayem S MacAusland-Berg Joshua J Ng Chi Ying CY Chibbar Rajni R Napper Scott S Raptis Leda L Vizeacoumar Frederick F Vizeacoumar Franco F Bonham Keith K Lukong Kiven Erique KE
Oncotarget 20171206 68
The human fyn-related kinase (FRK) is a non-receptor tyrosine kinase known to have tumor suppressor activity in breast cancer cells. However, its mechanism of action has not been fully characterized. We generated FRK-stable MDA-MB-231 breast cancer cell lines and analyzed the effect on cell proliferation, migration, and invasiveness. We also used kinome analysis to identify potential FRK-regulated signaling pathways. We employed both immunoblotting and RT-PCR to identify/validate FRK-regulated t ...[more]