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Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis.

ABSTRACT: It was recently reported that increased SOX9 expression drives tumor growth and promotes cancer invasion during human tumorigenicity and metastasis. However, the prognostic value of SOX9 for the survival of patients with solid tumors remains controversial. The present meta-analysis was thus performed to highlight the link between dysregulated SOX9 expression and prognosis in cancer patients. A systematic literature search was conducted using the electronic databases PubMed, Web of Science and Embase to identify eligible studies. A random-effects meta-analytical model was employed to correlate SOX9 expression with overall survival (OS), disease-free survival (DFS) and clinicopathological features. In total, 17 studies with 3307 patients were eligible for the final analysis. Combined hazard ratios (HRs) and 95% confidence intervals (CIs) suggested that high SOX9 expression has an unfavourable impact on OS (HR = 1.66, 95% CI 1.36-2.02, P < 0.001) and DFS (HR = 3.54, 95% CI 2.29-5.47, P = 0.008) in multivariate analysis. Additionally, the pooled odds ratios (ORs) indicated that SOX9 over-expression is associated with large tumor size, lymph node metastasis, distant metastasis and a higher clinical stage. Overall, these results indicated that SOX9 over-expression in patients with solid tumors might be related to poor prognosis and could serve as a potential predictive marker of poor clinicopathological prognosis factor.

SUBMITTER: Ruan H

PROVIDER: S-EPMC5762580 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis.

Ruan Haihua H Hu Shuangyan S Zhang Hongyu H Du Gang G Li Xiaoting X Li Xiaobo X Li Xichuan X

Oncotarget 20171106 68

It was recently reported that increased SOX9 expression drives tumor growth and promotes cancer invasion during human tumorigenicity and metastasis. However, the prognostic value of SOX9 for the survival of patients with solid tumors remains controversial. The present meta-analysis was thus performed to highlight the link between dysregulated SOX9 expression and prognosis in cancer patients. A systematic literature search was conducted using the electronic databases PubMed, Web of Science and Em ...[more]

PMID: 29348895

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Project description:BackgroundEpithelial-mesenchymal transition (EMT) plays a crucial role in the progression and aggressiveness of colorectal carcinoma. E-cadherin is the best-characterized molecular marker of EMT, but its prognostic significance for patients with CRC remains inconclusive.MethodologyEligible studies were searched from the PubMed, Embase and Web of Science databases. Correlation between E-cadherin expression and clinicopathological features and prognosis was analyzed. Subgroup analysis was also performed according to study location, number of patients, quality score of studies and cut-off value.Principal findingsA total of 27 studies comprising 4244 cases met the inclusion criteria. Meta-analysis suggested that downregulated E-cadherin expression had an unfavorable impact on overall survival (OS) of CRC (n?=?2730 in 14 studies; HR?=?2.27, 95%CI: 1.63-3.17; Z?=?4.83; P?=?0.000). Subgroup analysis indicated that low E-cadherin expression was significantly associated with worse OS in Asian patients (n?=?1054 in 9 studies; HR?=?2.86, 95%CI: 2.13-3.7, Z?=?7.11; P?=?0.000) but not in European patients (n?=?1552 in 4 studies; HR?=?1.14, 95%CI: 0.95-1.35, Z?=?1.39; P?=?0.165). In addition, reduced E-cadherin expression indicated an unfavorable OS only when the cut off value of low E-cadherin expression was >50% (n?=?512 in 4 studies; HR?=?2.08, 95%CI 1.45-2.94, Z?=?4.05; P?=?0.000). Downregulated E-cadherin expression was greatly related with differentiation grade, Dukes' stages, lymphnode status and metastasis. The pooled OR was 0.36(95%CI: 0.19-0.7, Z?=?3.03, P?=?0.002), 0.34(95%CI: 0.21-0.55, Z?=?6.61, P?=?0.000), 0.49(95%CI: 0.32-0.74, Z?=?3.02, P?=?0.002) and 0.45(95%CI: 0.22-0.91, Z?=?3.43, P?=?0.001), respectively.ConclusionsThis study showed that low or absent E-cadherin expression detected by immunohistochemistry served as a valuable prognostic factor of CRC. However, downregulated E-cadherin expression seemed to be associated with worse prognosis in Asian CRC patients but not in European CRC patients. Additionally, this meta-analysis suggested that the negative threshold of E-cadherin should be >50% when we detected its expression in the immunohistochemistry stain.

Dataset Information

Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis.

Publications

Upregulated SOX9 expression indicates worse prognosis in solid tumors: a systematic review and meta-analysis.

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