Ontology highlight
ABSTRACT:
SUBMITTER: Majumder M
PROVIDER: S-EPMC5762661 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Majumder Mousumi M Dunn Leanna L Liu Ling L Hasan Asma A Vincent Krista K Brackstone Muriel M Hess David D Lala Peeyush K PK
Scientific reports 20180110 1
We show that Cyclooxygenase-2 over-expression induces an oncogenic microRNA miR655 in human breast cancer cells by activation of EP4. MiR655 expression positively correlated with COX-2 in genetically disparate breast cancer cell lines and increased in all cell lines when grown as spheroids, implicating its link with stem-like cells (SLCs). Ectopic miR655 over-expression in MCF7 and SKBR3 cells resulted in increased proliferation, migration, invasion, spheroid formation and Epithelial to Masenchy ...[more]