Ontology highlight
ABSTRACT:
SUBMITTER: Tseng KY
PROVIDER: S-EPMC5763030 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Tseng Kuan-Yin KY Anttila Jenni E JE Khodosevich Konstantin K Tuominen Raimo K RK Lindahl Maria M Domanskyi Andrii A Airavaara Mikko M
Molecular therapy : the journal of the American Society of Gene Therapy 20170921 1
Cerebral ischemia activates endogenous reparative processes, such as increased proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and migration of neural progenitor cells (NPCs) toward the ischemic area. However, this reparative process is limited because most of the NPCs die shortly after injury or are unable to arrive at the infarct boundary. In this study, we demonstrate for the first time that endogenous mesencephalic astrocyte-derived neurotrophic factor (MANF) prote ...[more]