Ontology highlight
ABSTRACT:
SUBMITTER: Lavtar P
PROVIDER: S-EPMC5764259 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lavtar Polona P Rudolf Gorazd G Maver Aleš A Hodžić Alenka A Starčević Čizmarević Nada N Živković Maja M Šega Jazbec Saša S Klemenc Ketiš Zalika Z Kapović Miljenko M Dinčić Evica E Raičević Ranko R Sepčić Juraj J Lovrečić Luca L Stanković Aleksandra A Ristić Smiljana S Peterlin Borut B
PloS one 20180111 1
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy cont ...[more]