Ontology highlight
ABSTRACT:
SUBMITTER: Pilling LC
PROVIDER: S-EPMC5764389 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Pilling Luke C LC Kuo Chia-Ling CL Sicinski Kamil K Tamosauskaite Jone J Kuchel George A GA Harries Lorna W LW Herd Pamela P Wallace Robert R Ferrucci Luigi L Melzer David D
Aging 20171201 12
We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10<sup>-8</sup>), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including <i>MC2R</i> intronic variants (codin ...[more]