Ontology highlight
ABSTRACT:
SUBMITTER: Bhome R
PROVIDER: S-EPMC5764398 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Bhome Rahul R Goh Rebecca W RW Bullock Marc D MD Pillar Nir N Thirdborough Stephen M SM Mellone Massimiliano M Mirnezami Reza R Galea Dieter D Veselkov Kirill K Gu Quan Q Underwood Timothy J TJ Primrose John N JN De Wever Olivier O Shomron Noam N Sayan A Emre AE Mirnezami Alex H AH
Aging 20171201 12
Colorectal cancer is a global disease with increasing incidence. Mortality is largely attributed to metastatic spread and therefore, a mechanistic dissection of the signals which influence tumor progression is needed. Cancer stroma plays a critical role in tumor proliferation, invasion and chemoresistance. Here, we sought to identify and characterize exosomal microRNAs as mediators of stromal-tumor signaling. <i>In vitro</i>, we demonstrated that fibroblast exosomes are transferred to colorectal ...[more]