Ontology highlight
ABSTRACT:
SUBMITTER: Gourronc FA
PROVIDER: S-EPMC5764822 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Gourronc Francoise A FA Robertson Larry W LW Klingelhutz Aloysius J AJ
Environmental science and pollution research international 20170711 17
Inflammation in adipose tissue is recognized as a causative factor in the development of type II diabetes. Adipocyte hypertrophy as well as bacterial and environmental factors have been implicated in causing inflammation in mature adipocytes. Exposure to persistent organic pollutants such as polychlorinated biphenyls (PCBs) has been associated with the development of type II diabetes. We show here that PCB126, a dioxin-like PCB, activates a robust proinflammatory state in fat cell precursors (pr ...[more]